CD8+ T-Cell Subpopulations in Human Abdominal Aortic Aneurysm Lesion

CD8+ T-cell subpopulations in human abdominal aortic aneurysm lesion.

Abdominal Aortic Aneurysm Lesion To the Editor: We read with interest the article by Duftner et al1 reporting the prevalence of peripheral interferon(IFN)–producing CD4 CD28 and CD8 CD28 T cells in patients with small abdominal aortic aneurysm (AAA). Along with the recent description that Th1-type immune responses predominate in human end-stage AAA lesion,2,3 their observation further supports ...

Drug Therapy for Small Abdominal Aortic Aneurysm

Dear Editor,Abdominal aortic aneurysm is often asymptomatic, less recognized, and causes considerable mortality and morbidity, if missed. The incidence varies from country to country and the occurrence is influenced by modifiable (smoking, coronary heart disease, hypertension, dyslipidemia, and prolonged steroid therapy) and non-modifiable risk factors (increasing age, male gender, and positive...

Abdominal aortic aneurysm in giant cell arteritis

Aortic complications of giant cell arteritis are a rare cause of abdominal aortic aneurysm. Here, we describe a case of a ruptured aortic aneurysm in a patient with giant call arteritis (GCA) who was preoperatively suspected of having an infectious aortic aneurysm. Intraoperative inspection revealed infectious granulation tissue on the anterior wall of the abdominal aorta. GCA was finally confi...

CD43-mediated IFN-γ production by CD8+ T cells promotes abdominal aortic aneurysm in mice.

CD43 is a glycosylated surface protein abundantly expressed on lymphocytes. Its role in immune responses has been difficult to clearly establish, with evidence supporting both costimulatory and inhibitory functions. In addition, its contribution to disease pathogenesis remains elusive. Using a well-characterized murine model of elastase-induced abdominal aortic aneurysm (AAA) that recapitulates...

CD43-Mediated IFN-g Production by CD8 T Cells Promotes Abdominal Aortic Aneurysm in Mice